Links between analysis of surrogate endpoints and endogeneity
نویسندگان
چکیده
منابع مشابه
Links between analysis of surrogate endpoints and endogeneity.
There has been substantive interest in the assessment of surrogate endpoints in medical research. These are measures that could potentially replace 'true' endpoints in clinical trials and lead to studies that require less follow-up. Recent research in the area has focused on assessments using causal inference frameworks. Beginning with a simple model for associating the surrogate and true endpo...
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GAIL E. TUDOR. Survival Analysis Using Primary and Surrogate Endpoints. (Under the direction of TIMOTHY M. MORGAN) Current survival techniques do not provide a good method for handling clinical trials with a large percent of censored observations. Some methods that have been proposed to increase the power of analyses· include covariate adjustment, multivariate models, use of surrogate endpoints...
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A surrogate endpoint is defined as a biomarker intended to substitute for a clinical endpoint, such as an incidence, or mortality. The evidence supporting the linkage of a biomarker to accurately substitute for a clinical endpoint may be derived from epidemiologic studies, clinical trials, in vitro analysis, animal models, and simulated biologic systems. Analytical epidemiological studies of th...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2010
ISSN: 0277-6715
DOI: 10.1002/sim.4027